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One-Step Preparation of Reduction-Responsive Biodegradable Polymers as Efficient Intracellular Drug Delivery Platforms

Title data

Cai, Tongjiang ; Chen, Yangjun ; Wang, Yin ; Wang, Haibo ; Liu, Xiangsheng ; Jin, Qiao ; Agarwal, Seema ; Ji, Jian:
One-Step Preparation of Reduction-Responsive Biodegradable Polymers as Efficient Intracellular Drug Delivery Platforms.
In: Macromolecular Chemistry and Physics. Vol. 215 (October 2014) Issue 19 . - pp. 1848-1854.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201400311

Official URL: Volltext

Project information

Project financing: National Natural Science, Grant Numbers 51333005, 21174126, 51303154, 51025312; National Basic Research Program of China, Grant Number 2011CB606203; Research Fund for the Doctoral Program of Higher Education of China, Grant Numbers 20110101110037, 20120101130013, 20130101120177; Fundamental Research Funds for the Central Universities, Grant Number 2013QNA4047

Abstract in another language

Reduction-responsive biodegradable polymeric micelles based on functional 2-methylene-1,3-dioxepane (MDO) copolymers are developed and investigated for triggered doxorubicin (DOX) release. The MDO-based copolymers P(MDO-co-PEGMA-co-PDSMA) are synthesized via the simple one-step radical ring-opening copolymerization of MDO, poly(ethylene glycol) methyl ether methacrylate (PEGMA), and pyridyldisulfide ethylmethacrylate (PDSMA). The copolymers can self-assemble to form micelles in aqueous solution. DOX, a model anticancer drug, is loaded into the micelles with the drug loading content (DLC) of 11.3. The micelles can be disassembled under a reductive environment (10 × 10−3m glutathione), which results in a triggered drug release behavior. The glutathione-mediated intracellular drug release of DOX-loaded micelles is investigated against A549 cells. Confocal laser scanning microscopy (CLSM) results demonstrated that DOX-loaded micelles exhibits faster drug release in glutathione monoester (GSH-OEt)-pretreated A549 cells, compared with untreated and buthionine sulfoximine (BSO)-pretreated A549 cells. Based on the facile synthetic strategy, the reduction-sensitive biodegradable micelles with triggered intracellular drug release are promising for anticancer drug delivery.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biodegradable; drug release; 2-methylene-1;3-di­oxepane (MDO); reduction-responsive
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 12:03
Last Modified: 01 Apr 2015 12:03
URI: https://eref.uni-bayreuth.de/id/eprint/9582