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Functional 2-methylene-1,3-dioxepane terpolymer: a versatile platform to construct biodegradable polymeric prodrugs for intracellular drug delivery

Title data

Cai, Tongjiang ; Chen, Yangjun ; Wang, Yin ; Wang, Haibo ; Liu, Xiangsheng ; Jin, Qiao ; Agarwal, Seema ; Ji, Jian:
Functional 2-methylene-1,3-dioxepane terpolymer: a versatile platform to construct biodegradable polymeric prodrugs for intracellular drug delivery.
In: Polymer Chemistry. Vol. 5 (2014) Issue 13 . - pp. 4061-4068.
ISSN 1759-9954
DOI: https://doi.org/10.1039/C4PY00259H

Official URL: Volltext

Project information

Project financing: National Natural Science Foundation of China, Grant Numbers 51333005, 21174126, 51103126, 21374095, 51303154, 51025312; National Basic Research Program of China, Grant Number 2011CB606203; Research Fund for the Doctoral Program of Higher Education of China, Grant Numbers 20110101110037, 20120101130013, 20130101120177; Fundamental Research Funds for the Central Universities, Grant Number 2013QNA4047

Abstract in another language

Functional 2-methylene-1,3-dioxepane (MDO) terpolymers were explored here as a versatile platform to construct biodegradable pH sensitive polymeric prodrugs for intracellular drug delivery. A series of MDO-based biodegradable functional polyester P(MDO-co-PEGMA-co-PDSMA) with different compositions were synthesized by terpolymerization of MDO, poly(ethylene glycol) methyl ether methacrylate (PEGMA) and pyridyldisulfide ethylmethacrylate (PDSMA) via a simple one-pot radical ring-opening copolymerization. Mal-DOX, which contains a pH-sensitive hydrazone bond between doxorubicin (DOX) and the maleimide group, was covalently conjugated in one pot to free thiol groups of PDSMA units via thiol-ene click chemistry in the presence of tri(2-carboxyethyl)phosphine (TCEP). The DOX-conjugated P(MDO-co-PEGMA-co-PDSMA) can self-assemble into prodrug micelles. The diameter and morphology of the polymeric prodrug micelles were measured by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Because of the existence of the pH-sensitive hydrazone bonds, in vitro drug release results showed that the release of DOX was much faster at pH 5.5 than that at pH 7.4. Flow cytometry and fluorescence microscopy demonstrated that the prodrug micelles could be efficiently internalized by cancer cells. In vitro cytotoxicity showed that the DOX-conjugated prodrug micelles can strongly inhibit the proliferation of cancer cells remarkably. Importantly, this work provides a versatile strategy for the fabrication of biodegradable polymeric prodrug nanocarriers.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: RING-OPENING POLYMERIZATION; COPOLYMERS; METHACRYLATE; DOXORUBICIN; DESIGN; 5,6-BENZO-2-METHYLENE-1,3-DIOXEPANE; NANOPARTICLES; POLYESTERS; CHEMISTRY; MICELLES
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 02 Apr 2015 09:57
Last Modified: 02 Apr 2015 09:57
URI: https://eref.uni-bayreuth.de/id/eprint/9588