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Functional 2-methylene-1,3-dioxepane terpolymer: a versatile platform to construct biodegradable polymeric prodrugs for intracellular drug delivery

Titelangaben

Cai, Tongjiang ; Chen, Yangjun ; Wang, Yin ; Wang, Haibo ; Liu, Xiangsheng ; Jin, Qiao ; Agarwal, Seema ; Ji, Jian:
Functional 2-methylene-1,3-dioxepane terpolymer: a versatile platform to construct biodegradable polymeric prodrugs for intracellular drug delivery.
In: Polymer Chemistry. Bd. 5 (2014) Heft 13 . - S. 4061-4068.
ISSN 1759-9954
DOI: 10.1039/C4PY00259H

Volltext

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Angaben zu Projekten

Projektfinanzierung: National Natural Science Foundation of China, Grant Numbers 51333005, 21174126, 51103126, 21374095, 51303154, 51025312; National Basic Research Program of China, Grant Number 2011CB606203; Research Fund for the Doctoral Program of Higher Education of China, Grant Numbers 20110101110037, 20120101130013, 20130101120177; Fundamental Research Funds for the Central Universities, Grant Number 2013QNA4047

Abstract

Functional 2-methylene-1,3-dioxepane (MDO) terpolymers were explored here as a versatile platform to construct biodegradable pH sensitive polymeric prodrugs for intracellular drug delivery. A series of MDO-based biodegradable functional polyester P(MDO-co-PEGMA-co-PDSMA) with different compositions were synthesized by terpolymerization of MDO, poly(ethylene glycol) methyl ether methacrylate (PEGMA) and pyridyldisulfide ethylmethacrylate (PDSMA) via a simple one-pot radical ring-opening copolymerization. Mal-DOX, which contains a pH-sensitive hydrazone bond between doxorubicin (DOX) and the maleimide group, was covalently conjugated in one pot to free thiol groups of PDSMA units via thiol-ene click chemistry in the presence of tri(2-carboxyethyl)phosphine (TCEP). The DOX-conjugated P(MDO-co-PEGMA-co-PDSMA) can self-assemble into prodrug micelles. The diameter and morphology of the polymeric prodrug micelles were measured by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Because of the existence of the pH-sensitive hydrazone bonds, in vitro drug release results showed that the release of DOX was much faster at pH 5.5 than that at pH 7.4. Flow cytometry and fluorescence microscopy demonstrated that the prodrug micelles could be efficiently internalized by cancer cells. In vitro cytotoxicity showed that the DOX-conjugated prodrug micelles can strongly inhibit the proliferation of cancer cells remarkably. Importantly, this work provides a versatile strategy for the fabrication of biodegradable polymeric prodrug nanocarriers.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: RING-OPENING POLYMERIZATION; COPOLYMERS; METHACRYLATE; DOXORUBICIN; DESIGN; 5,6-BENZO-2-METHYLENE-1,3-DIOXEPANE; NANOPARTICLES; POLYESTERS; CHEMISTRY; MICELLES
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II > Lehrstuhl Makromolekulare Chemie II - Univ.-Prof. Dr. Andreas Greiner
Profilfelder > Advanced Fields > Polymer- und Kolloidforschung
Forschungseinrichtungen > Forschungszentren > Bayreuther Zentrum für Kolloide und Grenzflächen - BZKG
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Profilfelder
Profilfelder > Advanced Fields
Forschungseinrichtungen
Forschungseinrichtungen > Forschungszentren
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 02 Apr 2015 09:57
Letzte Änderung: 02 Apr 2015 09:57
URI: https://eref.uni-bayreuth.de/id/eprint/9588