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Degradable and Biocompatible Poly(N,N-dimethylaminoethyl Methacrylate-co-caprolactone)s as DNA Transfection Agents

Title data

Zhang, Yi ; Aigner, Achim ; Agarwal, Seema:
Degradable and Biocompatible Poly(N,N-dimethylaminoethyl Methacrylate-co-caprolactone)s as DNA Transfection Agents.
In: Macromolecular Bioscience. Vol. 13 (September 2013) Issue 9 . - pp. 1267-1275.
ISSN 1616-5187
DOI: https://doi.org/10.1002/mabi.201300043

Official URL: Volltext

Abstract in another language

This study describes the synthesis of a set of novel, degradable block copolymers for DNA transfection, and analyzes their physicochemical and biological properties. PEO macro-azoinitiators are used for the free radical copolymerization of DMAEMA and MDO, resulting in a series of different quaternized or non-quaternized block copolymers. All of the polymers show little cytotoxicity and full degradability, and thus, based on their favorable properties, may represent promising vectors for in vivo applications. Marked differences in DNA complexation efficacies and biological activities are observed, and one of the poly(PEG-co-(MDO-co-DMAEMA))s is identified as optimal for DNA transfection.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: copolymers, degradability, N,N-dimethylaminoethyl methacrylate (DMAEMA), DNA delivery, 2-methylene-1,3-dioxepane (MDO)
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 11:46
Last Modified: 01 Apr 2015 11:46
URI: https://eref.uni-bayreuth.de/id/eprint/9590