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Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications

Title data

Hanefeld, Phillip ; Westedt, Ullrich ; Wombacher, Ralf ; Kissel, Thomas ; Schaper, Andreas ; Wendorff, Joachim H. ; Greiner, Andreas:
Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications.
In: Biomacromolecules. Vol. 7 (July 2006) Issue 7 . - pp. 2086-2090.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm050642k

Official URL: Volltext

Abstract in another language

Poly(p-xylylene) (PPX) was deposited by chemical vapor deposition (CVD) on stainless steel substrates. These PPX films were coated by solution casting of poly( lactide)-poly(ethylene oxide)-poly(lactide) triblock copolymers (PLA-PEO-PLA) loaded with C-14-labeled paclitaxel. Adhesion of PLA-PEO-PLA on PPX substrate coatings was measured using the blister test method. Excellent adhesion of the block copolymers on PPX substrates was found. Stress behavior and film integrity of PLA-PEO-PLA was compared to pure PLA on unexpanded and expanded stent bodies and was found to be superior for the block copolymers. The release of paclitaxel from the biodegradable coatings was studied under physiological conditions using the scintillation counter method. Burst release of paclitaxel was observed from PLA-PEO-PLA layers regardless of composition, but an increase in paclitaxal loading was observed with increasing content of PEO.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: POLY(ETHYLENE GLYCOL); CONTROLLED-RELEASE; CORONARY-ARTERIES; HYDROGELS; CARRIERS; LACTIDE
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 13:17
Last Modified: 01 Apr 2015 13:17
URI: https://eref.uni-bayreuth.de/id/eprint/9686