Thermo-Switchable Antibacterial Activity

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Mattheis, Claudia ; Zhang, Yi ; Agarwal, Seema:
Thermo-Switchable Antibacterial Activity.
In: Macromolecular Bioscience. Bd. 12 (2012) Heft 10 . - S. 1401-1412.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.201200207

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Abstract

A copolymer system of 2-aminoethyl methacrylate and N-isopropylacrylamide comprises novel properties: changes in conformation and hydrophilicity upon heating influence the antibacterial activity and result in a switchable biocidal effect. The copolymers are characterized via NMR, MALDI-ToF MS, phase transition behavior, and antibacterial tests with E. coli or B. subtilis. MIC and MBC are determined using standard dilution methods, temperature-dependence via incubation at different temperatures and cytotoxicity by MTT tests. The copolymers exhibit lower MIC in globule than coil conformation, crosslinking on cotton results in non-leaching materials with better antibacterial activity above than below the phase-transition point.