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Thermo-Switchable Antibacterial Activity

Title data

Mattheis, Claudia ; Zhang, Yi ; Agarwal, Seema:
Thermo-Switchable Antibacterial Activity.
In: Macromolecular Bioscience. Vol. 12 (October 2012) Issue 10 . - pp. 1401-1412.
ISSN 1616-5187
DOI: https://doi.org/10.1002/mabi.201200207

Official URL: Volltext

Project information

Project financing: Philipps-Universitat Marburg

Abstract in another language

A copolymer system of 2-aminoethyl methacrylate and N-isopropylacrylamide comprises novel properties: changes in conformation and hydrophilicity upon heating influence the antibacterial activity and result in a switchable biocidal effect. The copolymers are characterized via NMR, MALDI-ToF MS, phase transition behavior, and antibacterial tests with E. coli or B. subtilis. MIC and MBC are determined using standard dilution methods, temperature-dependence via incubation at different temperatures and cytotoxicity by MTT tests. The copolymers exhibit lower MIC in globule than coil conformation, crosslinking on cotton results in non-leaching materials with better antibacterial activity above than below the phase-transition point.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: antibacterial polymers; biocides; quaternary ammonium compounds; stimuli-sensitive polymers; water-soluble polymers
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 01 Apr 2015 11:25
Last Modified: 01 Apr 2015 11:25
URI: https://eref.uni-bayreuth.de/id/eprint/9787