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Functional Degradable Polymers via Radical Ring-Opening Polymerization and Click Chemistry

Title data

Maji, Samarendra ; Zheng, Mengyao ; Agarwal, Seema:
Functional Degradable Polymers via Radical Ring-Opening Polymerization and Click Chemistry.
In: Macromolecular Chemistry and Physics. Vol. 212 (1 December 2011) Issue 23 . - pp. 2573-2582.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201100375

Official URL: Volltext

Project information

Project financing: Alexander von Humboldt-Stiftung
Deutsche Forschungsgemeinschaft

Abstract in another language

The use of free-radical polymerization for the formation of an alkyne-functionalized polymer with ester units of polycaprolactone type in the backbone is shown. This is done by the copolymerization of a cyclic ketene acetal 2-methylene-1,3-dioxepane (MDO) with propargyl acrylate using a free radical initiator, azobis(isobutyronitrile). Structural characterization of the copolymers using 1D and 2D NMR techniques shows the random distribution and very high percentage of inclusion of alkyne groups onto the polymer backbone. The exemplary grafting of a biocompatible polymer poly(ethylene glycol) via azide-alkyne “click” chemistry is also shown. Hydrolytic degradation behavior and biocompatibility of the polymers (cytotoxicity) studies are also reported.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biocompatibility; click chemistry; cyclic ketene acetal; degradable polymers; radical ring-opening polymerization
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 12:14
Last Modified: 01 Apr 2015 12:14
URI: https://eref.uni-bayreuth.de/id/eprint/9800