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The correlation between protein stability and dipole moment : a critical test

Title data

Wunderlich, Michael ; Schmid, Franz X.:
The correlation between protein stability and dipole moment : a critical test.
In: Protein Engineering Design & Selection. Vol. 19 (August 2006) Issue 8 . - pp. 355-358.
ISSN 0269-2139
DOI: https://doi.org/10.1093/protein/gzl019

Official URL: Volltext

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Abstract in another language

Improving the stability of proteins is a major aim in basic and applied protein science. Querol and coworkers calculated changes in the quasi-electric dipole moment of a protein and used it as a simple criterion to predict stabilizing charge mutations. They employed this method to propose for the bacterial cold shock protein Bc-Csp a number of charge mutations that should have a strong influence on stability. We produced eight variants of Bc-Csp with such mutations and measured their stabilities experimentally. However, we could not find a correlation between the stability and the quasi dipole moment of these variants. Possibly, the quasi dipole moment reflects only a secondary aspect of the changes that are caused by charge mutations in a protein.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 16720692
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Professorship Biochemistry - Univ.-Prof. Dr. Franz Xaver Schmid
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professorship Biochemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 24 Apr 2015 08:12
Last Modified: 27 Apr 2016 05:50
URI: https://eref.uni-bayreuth.de/id/eprint/10644