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Diffusional barrier crossing in a two-state protein folding reaction

Title data

Jacob, Maik H. ; Geeves, Michael A. ; Holtermann, Georg ; Schmid, Franz X.:
Diffusional barrier crossing in a two-state protein folding reaction.
In: Nature Structural Biology. Vol. 6 (October 1999) Issue 10 . - pp. 923-926.
ISSN 1072-8368
DOI: https://doi.org/10.1038/13289

Abstract in another language

There has been some debate as to whether protein folding involves diffusive chain motions and thus depends on solvent viscosity. The interpretation of folding kinetics in viscous solvents has remained difficult and controversial, in that viscogenic agents affect folding rates not only by increasing solvent viscosity but also by increasing protein stability. By carefully choosing experimental conditions, we can now eliminate the effect on stability and show that the folding dynamics of the cold shock protein CspB are viscosity dependent. Thus Kramers' theory of reaction rates rather than transition state theory should be used to describe this folding reaction.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 10504725
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Professorship Biochemistry - Univ.-Prof. Dr. Franz Xaver Schmid
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professorship Biochemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 27 May 2015 07:05
Last Modified: 28 May 2015 06:49
URI: https://eref.uni-bayreuth.de/id/eprint/14338