on the publication serverTitle data
Bohle, D. Scott ; Dinnebier, Robert E. ; Madsen, Sara K. ; Stephens, Peter W.:
Characterization of the products of the heme detoxification pathway in malarial late trophozoites by X-ray diffraction.
In: The Journal of Biological Chemistry.
Vol. 272
(1997)
.
- pp. 713-716.
ISSN 1083-351X
DOI: https://doi.org/10.1074/jbc.272.2.713
Abstract in another language
In a process inhibited by the quinoline antimalarial drugs, Plasmodia detoxify heme released during the degradation of hemoglobin by aggregating it into malarial pigment, an insoluble crystalline heme coordination polymer. Synchrotron x-ray powder diffraction patterns for intact desiccated malarial trophozoites and synthetic beta-hematin have been measured; both materials correspond to a single crystalline triclinic lattice with unit cell parameters a = 12.2176(4), b = 14.7184(5), c = 8.0456(3) A; alpha = 90.200(2), beta = 96.806(3), gamma = 97.818(3) degrees and Z = 2. These results unambiguously demonstrate that hemozoin crystallites are identical to synthetic beta-hematin.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Mathematics, Physics und Computer Science > Group Material Sciences > Chair Crystallography Faculties Faculties > Faculty of Mathematics, Physics und Computer Science Faculties > Faculty of Mathematics, Physics und Computer Science > Group Material Sciences |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 530 Physics |
| Date Deposited: | 15 Jun 2016 09:02 |
| Last Modified: | 15 Jun 2016 09:02 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/32684 |
