on the publication serverTitle data
Feoktistova, Natalia ; Stoychev, Georgi ; Puretskiy, Nikolay ; Ionov, Leonid ; Volodkin, Dmitry:
Porous thermo-responsive pNIPAM microgels.
In: European Polymer Journal.
Vol. 68
(July 2015)
.
- pp. 650-656.
ISSN 1873-1945
DOI: https://doi.org/10.1016/j.eurpolymj.2015.03.040
Abstract in another language
Thermo-responsive poly(N-isopropylacrylamide) (pNIPAM) gels are very attractive for biological applications due to a phase transition at temperature (32 degrees C) closed to that of biologically relevant. This stimulates the usage of this polymer for cell culture, biosensing, drug delivery, etc. Herein we develop a new simple approach to synthesize porous pNIPAM microgels by hard templating using porous CaCO3 cores. For this purpose, the mesoporous CaCO3 cores have been infiltrated with pNIPAM-4-acryloylbenzophenone (pNIPAM-ABP) followed by chemical crosslinking of the polymer molecules by UV-light and further core removal in HCl. The formed microgels possess reversible temperature response with LCST similar to that of the pure pNIPAM-ABP. Phase transition results in dramatic collapse of the porous microgels with the decrease of their size by up to ten times due to the pore closure. The porous structure is reorganized after the reversible heating-cooling cycle resulting in closure of larger pores and thus more homogeneous polymer distribution. The microgels are both temperature and pH sensitive that makes them attractive for drug delivery applications.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Professor Biofabrication |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 23 Jun 2017 10:39 |
| Last Modified: | 14 Jul 2020 11:02 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/37960 |
