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Mechanical Characterization of Micrometric Chitosan-Coated Vesicle by Atomic Force Microscopy

Title data

Rinaudo, M. ; Quemeneur, F. ; Dubreuil, Frederic ; Fery, Andreas ; Pépin-Donat, B.:
Mechanical Characterization of Micrometric Chitosan-Coated Vesicle by Atomic Force Microscopy.
In: International Journal of Polymer Analysis and Characterization. Vol. 18 (November 2013) Issue 8 . - pp. 617-626.
ISSN 1563-5341
DOI: https://doi.org/10.1080/1023666X.2013.842352

Official URL: Volltext

Abstract in another language

This article reports the main results obtained for the stabilization of DOPC liposomes by coating with chitosan. We investigated the compression between two planes of isolated GUV, combining force spectroscopy measurements with scanning probe microscopy (SPM) and epifluorescence microscopy observations. We obtained reproducible and reversible force-deformation curves for individual vesicles in the range of small deformation (relative deformation up to 0.3). Force-deformation curves were analyzed using a simple elastic model, which well describes the observed radius-dependency of the force response and allows determining the stretching modulus for bare vesicle and effective bending and stretching moduli for chitosan-coated membranes. Results first show that chitosan coating increases the effective stretching modulus of the lipid membranes, second, confirm that chitosan is adsorbed flat on the membrane, and finally lead us to assume that the chitosan coating structure can be regarded as a physical network of connected chitosan patches.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 05 Dec 2014 10:53
Last Modified: 10 Feb 2015 13:58
URI: https://eref.uni-bayreuth.de/id/eprint/3931