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Generation of Multi-Shell Magnetic Hybrid Nanoparticles by Encapsulation of Genetically Engineered and Fluorescent Bacterial Magnetosomes with ZnO and SiO₂

Title data

Borg, Sarah ; Rothenstein, Dirk ; Bill, Joachim ; Schüler, Dirk:
Generation of Multi-Shell Magnetic Hybrid Nanoparticles by Encapsulation of Genetically Engineered and Fluorescent Bacterial Magnetosomes with ZnO and SiO₂.
In: Small. Vol. 11 (2 September 2015) Issue 33 . - pp. 4209-4217.
ISSN 1613-6829
DOI: https://doi.org/10.1002/smll.201500028

Abstract in another language

Magnetic nanoparticles (MNPs) have great potential in biomedical applications, but the chemical synthesis of size-controlled and functionalized core–shell MNPs remain challenging. Magnetosomes produced by the magnetotactic bacterium Magnetospirillum gryphiswaldense are naturally uniform and chemically pure magnetite MNPs with superior magnetic characteristics. Here, additional functionalities are made possible by the incorporation of biomolecules on the magnetosome surface; the magnetosome system is then chemically encapsulated with an inorganic coating. The novel multishell nanoparticles consist of the magnetosome core—which includes the magnetite crystal, the magnetosome membrane, and additional moieties, such as the enhanced green fluorescent protein (EGFP) and peptides—and an outer shell, comprising either silica or zinc oxide. Coating the functionalized magnetosomes with silica improves their colloidal stability and preserves the EGFP fluorescence in the presence of proteases and detergents. In addition, the surface charge of magnetosomes can be adjusted by varying the coating. This method will be useful for the versatile generation of new, multifunctional, multishell, and magnetic hybrid nanomaterials with potential applications in various biotechnological fields.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology > Chair Microbiology - Univ.-Prof. Dr. Dirk Schüler
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology
Result of work at the UBT: No
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 08 Sep 2017 07:15
Last Modified: 04 Apr 2019 09:25
URI: https://eref.uni-bayreuth.de/id/eprint/39411