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Probing Multivalent Host-Guest Interactions between Modified Polymer Layers by Direct Force Measurement

Title data

Kaftan, Oznur ; Tumbiolo, Simonetta ; Dubreuil, Frederic ; Auzely-Velty, Rachel ; Fery, Andreas ; Papastavrou, Georg:
Probing Multivalent Host-Guest Interactions between Modified Polymer Layers by Direct Force Measurement.
In: The Journal of Physical Chemistry B. Vol. 115 (2011) Issue 24 . - pp. 7726-7735.
ISSN 1520-5207
DOI: https://doi.org/10.1021/jp110939c

Official URL: Volltext

Abstract in another language

The adhesion behavior between modified polysaccharide layers capable of forming host-guest complexes has been determined by direct force measurements with the atomic force microscope (AFM). Polysaccharides bearing either host or guest moieties were obtained by derivatization of chitosan with pendant beta-cyclodextrin (CD) and adamantane (AD) moieties, respectively. These modified polysaccharides were covalently immobilized either to flat surfaces or to AFM-probes. The number of interacting polymer segments has been reduced significantly by covalently immobilizing chitosan to an AFM-tip with small radius and measuring the forces between the protruding polymer segments and a chitosan layer immobilized to a flat surface. By this approach, it was possible to determine the interaction between polymer layers on the level of single polymer strands. To separate contributions to the adhesion due to the formation of host-guest complexes from unspecific interactions, we performed measurements between various combinations of chitosan derivatives. With the same polymer probe of adamantane-modified chitosan, the interaction against a number of different chitosan layers has been determined, including ones that are not able to form host-guest complexes, such as unmodified chitosan or beta-cyclodextrin modified chitosan, which has been blocked previously by addition of adamantane. The resulting adhesion behavior has been analyzed in terms of the total work of adhesion, the number of rupture events, and the corresponding lengths of the polymer segments as well as rupture forces. A dear difference has been found for systems where the formation of host-guest complexes is possible in comparison to the absence of specific multivalent interaction between the polysaccharide layers. In particular, the work of adhesion is increasing up to an order of magnitude upon the formation of host-guest complexes between the chitosan layers.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 08 Dec 2014 08:29
Last Modified: 18 Feb 2016 08:25
URI: https://eref.uni-bayreuth.de/id/eprint/3976