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Modified vibrating-mesh nozzles for advanced spray-drying applications

Title data

Beck-Broichsitter, Moritz ; Paulus, Ilka E. ; Greiner, Andreas ; Kissel, Thomas:
Modified vibrating-mesh nozzles for advanced spray-drying applications.
In: European Journal of Pharmaceutics and Biopharmaceutics. Vol. 92 (2015) . - pp. 96-101.
ISSN 1873-3441
DOI: https://doi.org/10.1016/j.ejpb.2015.03.001

Abstract in another language

This work describes uniform polymer coatings allowing for an adjustment of the orifice dimension of vibrating-mesh nozzles and therefore, size of emerging formulation droplets and dried particles, which is of general interest for diverse spray-drying applications. Chemical vapor deposition of poly(p-xylylene) (PPXN) on aperture templates of the B-90 spray-dryer (orifice diameters: ∼4.0 μm) caused a reduction of the opening cross-sections of ∼50%. Thus, a more efficient formulation atomization was observed (finer droplets). Likewise, application of PPXN-coated, rather than plain nozzles, resulted in significantly smaller (particle diameter: 1.3 vs. 3.6 μm) and narrower distributed (span: ∼1.4 vs. ∼1.8) sildenafil-loaded poly(lactide-co-glycolide) microparticles. Prediction of the size of spray-dried microparticles using the size results of atomized droplets (“residual core method”) was shown to be in agreement with the observed values. Formulations prepared with plain and PPXN-coated nozzles exhibited a sustained sildenafil release profile with mean dissolution times of ∼1.5 and ∼4.0 h, respectively. Regardless of the starting aperture template, any desired orifice dimension and therefore, dried particle size could be achieved by generating adequate polymer deposits.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 16 Aug 2018 07:53
Last Modified: 16 Aug 2018 07:53
URI: https://eref.uni-bayreuth.de/id/eprint/45498