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Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3′-diindolylmethane ligand

Title data

Dankhoff, Katja ; Ahmad, Aamir ; Weber, Birgit ; Biersack, Bernhard ; Schobert, Rainer:
Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3′-diindolylmethane ligand.
In: Journal of Inorganic Biochemistry. Vol. 194 (2019) . - pp. 1-6.
ISSN 1873-3344
DOI: https://doi.org/10.1016/j.jinorgbio.2019.02.005

Abstract in another language

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry IV > Chair Anorganic Chemistry IV - Univ.-Prof. Dr. Birgit Weber
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 08 Mar 2019 06:58
Last Modified: 08 Mar 2019 06:58
URI: https://eref.uni-bayreuth.de/id/eprint/47897