Enlarging the toolbox for allergen epitope definition with an allergen-type model protein

Titelangaben

Berkner, Hanna ; Seutter von Loetzen, Christian ; Hartl, Maximilian J. ; Randow, Stefanie ; Gubesch, Michaela ; Vogel, Lothar ; Husslik, Felix ; Reuter, Andreas ; Lidholm, Jonas ; Ballmer-Weber, Barbara ; Vieths, Stefan ; Rösch, Paul ; Schiller, Dirk:
Enlarging the toolbox for allergen epitope definition with an allergen-type model protein.
In: PLoS One. Bd. 9 (2014) Heft 10 . - e111691.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0111691

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Abstract

BACKGROUND: Birch pollen-allergic subjects produce polyclonal cross-reactive IgE antibodies that mediate pollen-associated food allergies. The major allergen Bet v 1 and its homologs in plant foods bind IgE in their native protein conformation. Information on location, number and clinical relevance of IgE epitopes is limited. We addressed the use of an allergen-related protein model to identify amino acids critical for IgE binding of PR-10 allergens.