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Enlarging the toolbox for allergen epitope definition with an allergen-type model protein

Title data

Berkner, Hanna ; Seutter von Loetzen, Christian ; Hartl, Maximilian J. ; Randow, Stefanie ; Gubesch, Michaela ; Vogel, Lothar ; Husslik, Felix ; Reuter, Andreas ; Lidholm, Jonas ; Ballmer-Weber, Barbara ; Vieths, Stefan ; Rösch, Paul ; Schiller, Dirk:
Enlarging the toolbox for allergen epitope definition with an allergen-type model protein.
In: PLoS One. Vol. 9 (2014) Issue 10 . - e111691.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0111691

Official URL: Volltext

Abstract in another language

BACKGROUND: Birch pollen-allergic subjects produce polyclonal cross-reactive IgE antibodies that mediate pollen-associated food allergies. The major allergen Bet v 1 and its homologs in plant foods bind IgE in their native protein conformation. Information on location, number and clinical relevance of IgE epitopes is limited. We addressed the use of an allergen-related protein model to identify amino acids critical for IgE binding of PR-10 allergens.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 500 Natural sciences
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 19 Dec 2014 09:30
Last Modified: 30 Jan 2019 11:18
URI: https://eref.uni-bayreuth.de/id/eprint/5063