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Manganese catalyzed ß‐methylation of alcohols by methanol

Title data

Kempe, Rhett ; Schlagbauer, Martin ; Kallmeier, Fabian ; Irrgang, Torsten:
Manganese catalyzed ß‐methylation of alcohols by methanol.
In: Angewandte Chemie International Edition. (19 November 2019) .
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201912055

Abstract in another language

We report an earth‐abundant metal catalyzed double and single methylation of alcohols. A manganese catalyst, which operates at low catalyst loadings and short reaction times, mediates these reactions efficiently. A broad scope of primary and secondary alcohols including purely aliphatic examples and 1,2‐aminoalcohols can be methylated. In addition, alcohol methylation for the synthesis of pharmaceuticals has been demonstrated. The catalyst system tolerates many functional groups among them hydrogenation sensitive examples and upscaling is easily achieved. Mechanistic investigations are indicative of a borrowing hydrogen or hydrogen autotransfer mechanism involving a bimetallic K‐Mn catalyst. The catalyst accepts hydrogen as a proton and a hydride from alcohols efficiently and reacts with a chalcone via hydride transfer.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: early view
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry II > Chair Anorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 21 Nov 2019 08:04
Last Modified: 21 Nov 2019 08:04
URI: https://eref.uni-bayreuth.de/id/eprint/53355