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Pandey, Rahul ; Heidmann, Stefan ; Lehner, Christian F.:
Epithelial re-organization and dynamics of progression through mitosis in Drosophila separase complex mutants.
In: Journal of Cell Science.
Bd. 118
(2005)
Heft 4
.
- S. 733-742.
ISSN 1477-9137
DOI: https://doi.org/10.1242/jcs.01663
Abstract
Separase cleaves a subunit of the cohesin complex and thereby promotes sister chromatid separation during mitotic and meiotic divisions. Drosophila separase associates with regulatory subunits encoded by the pimples and three rows genes. Three rows and Pimples, the Drosophila securin, are required for sister chromatid separation during mitosis. Budding yeast separase provides other functions in addition to cohesin subunit cleavage, which are required for spindle organization and temporal regulation during exit from mitosis. Therefore, using time-lapse imaging in live embryos, we have carefully analyzed progression through mitosis in pimples and three rows mutants. We demonstrate that despite the total failure of sister chromatid separation, exit from mitosis, including a complete cytokinesis, proceeds with only a minor temporal delay in the epidermal cells of these mutants. Interestingly, however, pronounced defects in the epithelial organization develop in the following interphase, indicating that the separase complex is not only important for genetic stability but also and perhaps indirectly for epithelial integrity.
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| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | cytokinesis; centrosome; junctional dynamics; mitotic exit network (MEN); Cdc fourteen early anaphase release (FEAR); separase; sister-chromatid separation; mitotic exit; phosphatase CDC14; proteolytic cleavage; anaphase transition; DNA-Replication; fission yeast; meiosis-I; CYCLIN-B; protein |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Genetik Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
| Eingestellt am: | 06 Mär 2020 10:46 |
| Letzte Änderung: | 06 Mär 2020 11:02 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/54532 |