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The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H₃ variant CID

Title data

Jäger, Hubert ; Rauch, Melanie ; Heidmann, Stefan:
The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H₃ variant CID.
In: Chromosoma. Vol. 113 (2005) Issue 7 . - pp. 350-361.
ISSN 1432-0886
DOI: https://doi.org/10.1007/s00412-004-0322-4

Abstract in another language

The centromere-specific histone H3 variant CENP-A plays a crucial role in kinetochore specification and assembly. We chose a genetic approach to identify interactors of the Drosophila CENP-A homolog CID. Overexpression of cid in the proliferating eye imaginal disk results in a rough eye phenotype, which is dependent on the ability of the overexpressed protein to localize to the kinetochore. A screen for modifiers of the rough eye phenotype identified mutations in the Drosophila condensin subunit gene Cap-G as interactors. Yeast two-hybrid experiments also reveal an interaction between CID and Cap-G. While chromosome condensation in Cap-G mutant embryos appears largely unaffected, massive defects in sister chromatid segregation occur during mitosis. Taken together, our results suggest a link between the chromatin condensation machinery and kinetochore structure.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: mitotic chromosome architecture; sister chromatid segregation; cell-cycle progression; vertebrate cells; topoisomerase-II; caenorhabditis-elegans; CENP-C; protein; mitosis; segregation
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 06 Mar 2020 10:52
Last Modified: 06 Mar 2020 11:02
URI: https://eref.uni-bayreuth.de/id/eprint/54533