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RNA editing in kinetoplastid protozoa

Title data

Stuart, K. ; Allen, T. E. ; Heidmann, Stefan ; Seiwert, S. D.:
RNA editing in kinetoplastid protozoa.
In: Microbiology and Molecular Biology Reviews. Vol. 61 (March 1997) Issue 1 . - pp. 105-120.
ISSN 1098-5557

Official URL: Volltext

Abstract in another language

Mitochondrial transcripts in kinetoplastids undergo remarkable posttranscriptional editing by uridylate insertion and deletion. The often dramatic remodelling of pre-mRNA sequences is directed by small guide RNAs (gRNAs) to produce mature mRNAs. In vitro analyses of editing have been used to determine the mechanism of editing and show that editing occurs by a series of enzyme-catalyzed steps. They also show that chimeric gRNA/mRNA molecules are not editing intermediates as proposed but are aberrant end products of editing. The complexes and molecules that catalyze editing are now being identified and characterized. The origin of editing, its developmental regulation which helps control the switching between terminal respiratory systems during the life cycle of trypanosomes, and other areas for future study are discussed.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Mitochondrial Ribonucleoprotein Complexes; Leishmania-Tarentolae Mitochondria; Trypanosoma-Brucei Mitochondria; Multiple Guide RNAS; Life-Cycle Stages; B Messenger-RNA; Crithidia-Fasciculata; NADH Dehydrogenase; Maxicircle DNA; Reading Frames
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Result of work at the UBT: No
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 12 Mar 2020 12:48
Last Modified: 12 Mar 2020 12:48
URI: https://eref.uni-bayreuth.de/id/eprint/54608