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Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons

Titelangaben

Hassan, Amira ; Rodriguez, Pablo Araguas ; Heidmann, Stefan ; Walmsley, Emma L. ; Aughey, Gabriel N. ; Southall, Tony D.:
Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons.
In: eLife. Bd. 9 (2020) . - e55159.
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.55159

Abstract

Condensin complexes are essential for mitotic chromosome assembly and segregation during cell divisions, however, little is known about their functions in post-mitotic cells. Here we report a role for the condensin I subunit Cap-G in Drosophila neurons. We show that, despite not requiring condensin for mitotic chromosome compaction, post-mitotic neurons express Cap-G. Knockdown of Cap-G specifically in neurons (from their birth onwards) results in developmental arrest, behavioural defects, and dramatic gene expression changes, including reduced expression of a subset of neuronal genes and aberrant expression of genes that are not normally expressed in the developing brain. Knockdown of Cap-G in mature neurons results in similar phenotypes but to a lesser degree. Furthermore, we see dynamic binding of Cap-G at distinct loci in progenitor cells and differentiated neurons. Therefore, Cap-G is essential for proper gene expression in neurons and plays an important role during the early stages of neuronal development.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Genetik
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 22 Apr 2020 06:10
Letzte Änderung: 11 Apr 2024 10:09
URI: https://eref.uni-bayreuth.de/id/eprint/54988