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Single-Particle Tracking Reveals Anti-Persistent Subdiffusion in Cell Extracts

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Speckner, Konstantin ; Weiss, Matthias:
Single-Particle Tracking Reveals Anti-Persistent Subdiffusion in Cell Extracts.
In: Entropy. Bd. 23 (13 Juli 2021) Heft 7 . - 892.
ISSN 1099-4300
DOI: https://doi.org/10.3390/e23070892

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Abstract

Single-particle tracking (SPT) has become a powerful tool to quantify transport phenomena in complex media with unprecedented detail. Based on the reconstruction of individual trajectories, a wealth of informative measures become available for each particle, allowing for a detailed comparison with theoretical predictions. While SPT has been used frequently to explore diffusive transport in artificial fluids and inside living cells, intermediate systems, i.e., biochemically active cell extracts, have been studied only sparsely. Extracts derived from the eggs of the clawfrog Xenopus laevis, for example, are known for their ability to support and mimic vital processes of cells, emphasizing the need to explore also the transport phenomena of nano-sized particles in such extracts. Here, we have performed extensive SPT on beads with 20 nm radius in native and chemically treated Xenopus extracts. By analyzing a variety of distinct measures, we show that these beads feature an anti-persistent subdiffusion that is consistent with fractional Brownian motion. Chemical treatments did not grossly alter this finding, suggesting that the high degree of macromolecular crowding in Xenopus extracts equips the fluid with a viscoelastic modulus, hence enforcing particles to perform random walks with a significant anti-persistent memory kernel.

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Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: anomalous diffusion; random walk; single-particle tracking
Institutionen der Universität: Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie > Lehrstuhl Experimentalphysik I - Physik lebender Materie - Univ.-Prof. Dr. Matthias Weiss
Fakultäten
Fakultäten > Fakultät für Mathematik, Physik und Informatik
Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut
Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 530 Physik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 17 Aug 2021 07:53
Letzte Änderung: 24 Jan 2023 06:50
URI: https://eref.uni-bayreuth.de/id/eprint/66810