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Stiffness-Dependent In Vitro Uptake and Lysosomal Acidification of Colloidal Particles

Title data

Hartmann, Raimo ; Weidenbach, Marcel ; Neubauer, Martin Peter ; Fery, Andreas ; Parak, Wolfgang J.:
Stiffness-Dependent In Vitro Uptake and Lysosomal Acidification of Colloidal Particles.
In: Angewandte Chemie International Edition. Vol. 54 (2015) Issue 4 . - pp. 1365-1368.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201409693

Official URL: Volltext

Abstract in another language

The physico-chemical properties of colloidal particles determine their uptake into cells. For a series of microparticles only one parameter, the mechanical stiffness, was varied, whereas other parameters such as size, shape, and charge were kept constant. The uptake was monitored in situ by analyzing individual particle trajectories including the progress of endocytosis, derived from local pH measurements around each particle. Evidence is presented that soft particles with low stiffness are transported faster to lysosomes than stiffer ones.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 530 Physics
500 Science > 540 Chemistry
Date Deposited: 19 Mar 2015 09:22
Last Modified: 19 Mar 2015 09:22
URI: https://eref.uni-bayreuth.de/id/eprint/8404