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A sustainable catalytic pyrrole synthesis

Title data

Michlik, Stefan ; Kempe, Rhett:
A sustainable catalytic pyrrole synthesis.
In: Nature Chemistry. Vol. 5 (2013) Issue 2 . - pp. 140-144.
ISSN 1755-4349
DOI: https://doi.org/10.1038/nchem.1547

Abstract in another language

The pyrrole heterocycle is a prominent chemical motif and is found widely in natural products, drugs, catalysts and advanced materials. Here we introduce a sustainable iridium-catalysed pyrrole synthesis in which secondary alcohols and amino alcohols are deoxygenated and linked selectively via the formation of C-N and C-C bonds. Two equivalents of hydrogen gas are eliminated in the course of the reaction, and alcohols based entirely on renewable resources can be used as starting materials. The catalytic synthesis protocol tolerates a large variety of functional groups, which includes olefins, chlorides, bromides, organometallic moieties, amines and hydroxyl groups. We have developed a catalyst that operates efficiently under mild conditions.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Alcohols/chemistry;Alkenes/chemistry;Amines;Bromides/chemistry;Catalysis;Chlorides/chemistry;Green Chemistry Technology/methods;Hydrogen;Hydroxides/chemistry;Iridium;Molecular Structure;Organometallic Compounds/chemistry;Pyrroles/chemical synthesis
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry II > Chair Anorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 540 Chemistry
Date Deposited: 23 Mar 2015 07:49
Last Modified: 23 Mar 2015 07:49
URI: https://eref.uni-bayreuth.de/id/eprint/8762