Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Influence of Cation Size on the Co-crystallisation of Benzoic Acid with Different Benzoates

Title data

Butterhof, Christian ; Milius, Wolfgang ; Breu, Josef:
Influence of Cation Size on the Co-crystallisation of Benzoic Acid with Different Benzoates.
In: Zeitschrift für anorganische und allgemeine Chemie. Vol. 639 (4 January 2013) Issue 2 . - pp. 308-311.
ISSN 1521-3749
DOI: https://doi.org/10.1002/zaac.201200464

Abstract in another language

In the pharmaceutical industry many new active pharmaceutical ingredients (APIs) are marketed as carboxylic salts because of enhanced solubility and dissolution rates. These salts are, however, often hard to crystallise and/or exhibit a low degree of crystallinity. The reason may be the largely differing sizes of cation and anion. One way out of the resulting “coordination dilemma“ is the formation of co-crystals of the salt with its neutral acid which delivers additional coordination sites for the cation. In this line, the crystal structure of a new co-crystal of benzoic acid (HBz) and lithium benzoate (LiBz) with composition 1HBz·1LiBz was determined and was compared to published ionic co-crystals of other alkali salts with respect to the structure determining criteria: coordination number of the cation, ratio of HBz:Bz–, mode of coordination of the carboxylic groups (mono- or bidentate), and connectivity (edge- or corner-sharing) between neighbouring polyhedra. The new crystal structure is closely related to form A of 2HBz·1NaBz. Both crystal structures contain dimers with shared edges which are further connected by bridging bidentate ligands to tapes.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Co-crystals; Crystal structure; Benzoic acid; Lithium benzoate; Lithium
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry I > Chair Anorganic Chemistry I - Univ.-Prof. Dr. Josef Breu
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry I
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 Mar 2018 14:43
Last Modified: 20 Mar 2018 14:43
URI: https://eref.uni-bayreuth.de/id/eprint/9284