Titelangaben
Borne, Vincent ; Weiss, Matthias:
Robust spatiotemporal organization of mitotic events in mechanically perturbed C. elegans embryos.
In: Biophysical Journal.
Bd. 124
(18 März 2025)
Heft 6
.
- S. 913-922.
ISSN 1542-0086
DOI: https://doi.org/10.1016/j.bpj.2024.03.041
Abstract
Early embryogenesis of the nematode Caenorhabditis elegans progresses in an autonomous fashion within a protective chitin eggshell. Cell-division timing and the subsequent mechanically guided positioning of cells is virtually invariant between individuals, especially before gastrulation. Here, we have challenged this stereotypical developmental program in early stages by mechanically perturbing the embryo without breaking its eggshell. Compressing embryos to about two-thirds of their unperturbed diameter only resulted in markedly slower cell divisions. In contrast, compressing embryos to half of their native diameter frequently resulted in a loss of cytokinesis, yielding a non-natural syncytium that still allowed for multiple divisions of nuclei. Although the orientation of mitotic axes was strongly altered in the syncytium, key features of division timing and spatial arrangement of nuclei remained surprisingly similar to those of unperturbed embryos in the first few division cycles. This suggests that few, very robust mechanisms provide a basic and resilient program for safeguarding the early embryogenesis of C. elegans.
Weitere Angaben
Publikationsform: | Artikel in einer Zeitschrift |
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Begutachteter Beitrag: | Ja |
Institutionen der Universität: | Fakultäten > Fakultät für Mathematik, Physik und Informatik > Physikalisches Institut > Lehrstuhl Experimentalphysik I - Physik lebender Materie > Lehrstuhl Experimentalphysik I - Physik lebender Materie - Univ.-Prof. Dr. Matthias Weiss |
Titel an der UBT entstanden: | Ja |
Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
Eingestellt am: | 20 Mär 2025 07:49 |
Letzte Änderung: | 20 Mär 2025 08:28 |
URI: | https://eref.uni-bayreuth.de/id/eprint/92916 |