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PDMAEMA based gene delivery materials

Title data

Agarwal, Seema ; Zhang, Yi ; Maji, Samarendra ; Greiner, Andreas:
PDMAEMA based gene delivery materials.
In: Materials Today. Vol. 15 (2012) Issue 9 . - pp. 388-393.
ISSN 1873-4103

Official URL: Volltext

Abstract in another language

Gene transfection is the transfer of genetic material like DNA into cells. Cationic polymers which form nanocomplexes with DNA, so-called non-viral gene vectors, are a highly promising platform for efficient gene transfection. Despite intensive research efforts and some of the on-going clinical trials on gene transfection, none of the existing cationic polymer systems are generally acceptable for human gene therapy. Since the process of gene transfection is complex and puts different challenges and demands on the delivery system, there is a strong requirement for the design and development of a multifunctional system in a simple way. This review will discuss recent efforts in design, synthesis, and performance of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) nanocomplexes with DNA.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: IN-VITRO; TRANSFECTION EFFICIENCY; BIOPHYSICAL CHARACTERIZATION; CATIONIC POLYMETHACRYLATES; DNA DELIVERY; PLASMID DNA; POLYMERS; DESIGN; METHACRYLATE); VECTORS
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 31 Mar 2015 09:02
Last Modified: 31 Mar 2015 09:02
URI: https://eref.uni-bayreuth.de/id/eprint/9493