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Electrospun biodegradable nanofiber nonwovens for controlled release of proteins

Titelangaben

Maretschek, Sascha ; Greiner, Andreas ; Kissel, Thomas:
Electrospun biodegradable nanofiber nonwovens for controlled release of proteins.
In: Journal of Controlled Release. Bd. 127 (2008) Heft 2 . - S. 180-187.
ISSN 1873-4995
DOI: https://doi.org/10.1016/j.jconrel.2008.01.011

Volltext

Link zum Volltext (externe URL): Volltext

Abstract

Electrospinning of emulsions composed of an organic poly(L-lactide) solution and an aqueous protein solution yielded protein containing nanofiber nonwovens (NNs) having a mean fiber diameter of approximately 350 nm. Cytochrome C was chosen as a hydrophilic model protein for encapsulation. SEM imaging and gas adsorption measurements were carried out to determine morphology and surface characteristics of the different nanofiber nonwovens. Transmission electron microscopy was used to clarify the localization of the protein within the NN. PLLA NNs exhibited a highly hydrophobic surface which led to a slow wetting. It was shown that the protein release was dependent on the surface tension of the release medium. Electrospinning of emulsions consisting of an organic solution of PLLA and an aqueous solution of hydrophilic polymers yielded fibers composed of a polymer blend. The resulting NNs exhibited a less hydrophobic surface, which gave us the opportunity to tailor the release profile via this technology. Furthermore it was investigated how the addition of different amounts of hydrophilic polymer to the aqueous phase influenced the morphology of the resulting NNs. (c) 2008 Elsevier B.V. All rights reserved.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: electrospinning of emulsions; nanofiber nonwovens; drug delivery; cytochrome c; poly(L-lactide) (PLLA)
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II > Lehrstuhl Makromolekulare Chemie II - Univ.-Prof. Dr. Andreas Greiner
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 09 Apr 2015 12:43
Letzte Änderung: 30 Jun 2022 14:11
URI: https://eref.uni-bayreuth.de/id/eprint/9654