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Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings

Title data

Westedt, Ullrich ; Wittmar, Matthias ; Hellwig, Michael ; Hanefeld, Phillip ; Greiner, Andreas ; Schaper, Andreas ; Kissel, Thomas:
Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings.
In: Journal of Controlled Release. Vol. 111 (March 2006) Issue 1-2 . - pp. 235-246.
ISSN 1873-4995
DOI: https://doi.org/10.1016/j.jconrel.2005.12.012

Official URL: Volltext

Abstract in another language

Although substantial progress in catheter and stent design has contributed to the success of percutaneous transluminal angioplasty (PTA) of atherosclerotic disease, the incidence of restenosis caused by in-stent neointimal hyperplasia remains a serious problem. Therefore, stents with a non-degradable polymer coating showing controlled release of active ingredients have become ail attractive option for the site-specific delivery of anti-restenotic agents. Biodegradable coatings using polyesters, namely poly(lactic-co-glycolic acid) (PLGA) and different poly(vinyl alcohol)graft-poly(lactic-co-glycolic acid) (PVA-g-PLGA) as paclitaxel-eluting stent coating materials were investigated here to evaluate their influence on the release kinetic. Whereas PLGA showed sigmoid release behavior, the paclitaxel release from PVA-g-PLGA films was continuous over 40 days without initial drug burst. Wide angle X-ray diffraction confirmed that paclitaxel is dissolved in the polymer matrix. Paclitaxel crystallization can be observed at a drug load of >= 10%. The effect of drug loading oil polymer degradation was Studied in films prepared from PVA(300)-g-PLGA(30) with paclitaxel loadings of 5% and 15% over a time period of 6 weeks. The results suggest a surface-like erosion mechanism in films. A model stent (Jostent peripheral) coated with Parylene N, a poly(p-xylylene) (PPX) derivate, was covered with a second layer of PVA(300)-9-PLGA(15), and PVA(300)-g-PLGA(30) by using airbrush method. Morphology of coated stents, and film integrity after expansion from 3.12 to 5 mm was investigated by scanning electron microscopy (SEM). The devices resisted mechanical stress during stent expansion and merit further investigation under in vivo conditions. (c) 2006 Elsevier B.V. All rights reserved.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: angioplasty; restenosis; stents; poly(vinyl alcoliol)-grafl-poly(lactide-co-glycolide); paclitaxel
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 09 Apr 2015 12:57
Last Modified: 09 Apr 2015 12:57
URI: https://eref.uni-bayreuth.de/id/eprint/9690