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Role of electrospun nanofibers in stem cell technologies and tissue engineering

Title data

Boudriot, Ulrich ; Götz, Bernhard ; Dersch, Roland ; Greiner, Andreas ; Wendorff, Joachim H.:
Role of electrospun nanofibers in stem cell technologies and tissue engineering.
In: Macromolecular Symposia. Vol. 225 (May 2005) Issue 1 . - pp. 9-16.
ISSN 1521-3900
DOI: https://doi.org/10.1002/masy.200550702

Official URL: Volltext

Abstract in another language

Tissue engineering is a promising toot to manage structural and functional defects in bone and cartilage. To provide optimal conditions for three-dimensional cell growth the use of a scaffold is necessary. The aim of the study was to prove osteogenic differentiation of human mesenchymal stem cells (hMSC) onto a three-dimensional, nanostructured scaffold of electrospun poly (1-lactide)-nanofibers. HMSC were seeded onto this matrix and differentiated for 21 days. Cells clearly preferred a guided growth along the nanofibers and revealed no signs of cell-death. Osteogenic differentiation of hMSC onto the matrix has been demonstrated. Due to the fine structure, electrospun nanofibers promises to be an ideal scaffold for tissue engineering. They can be enriched with additives and are equally biocompatible and biodegradable.

Further data

Item Type: Article in a journal
Refereed: No
Keywords: biomaterials; mesenchymal stem cells; nanofibers; nanotechnology; tissue engineering
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 13 Apr 2015 13:13
Last Modified: 13 Apr 2015 13:13
URI: https://eref.uni-bayreuth.de/id/eprint/9701