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Semisynthesis of a homogeneous glycoprotein enzyme : ribonuclease C: part 1

Title data

Piontek, Christian ; Ring, Petra ; Harjes, Olaf ; Heinlein, Christian ; Mezzato, Stefano ; Lombana Sanchez, Jose Nelson ; Pöhner, Claudia ; Püttner, Markus ; Varón Silva, Daniel ; Martin, Andreas ; Schmid, Franz X. ; Unverzagt, Carlo:
Semisynthesis of a homogeneous glycoprotein enzyme : ribonuclease C: part 1.
In: Angewandte Chemie International Edition. Vol. 48 (2009) Issue 11 . - pp. 1936-1940.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.200804734

Abstract in another language

Seven in one blow: The efficient formation of mixed disulfides on the thiol-rich fusion protein A followed by subsequent intein cleavage gave the fragment B with all seven cysteines protected against oxidation. The native chemical ligation of B with synthetic glycopeptide thioesters provides glycoproteins.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 19173366
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Bioorganic Chemistry > Chair Bioorganic Chemistry - Univ.-Prof. Dr. Carlo Unverzagt
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Professor Biochemistry - Univ.-Prof. Dr. Franz Xaver Schmid
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Bioorganic Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professorship Biochemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 02 Jun 2015 08:57
Last Modified: 10 Apr 2018 11:31
URI: https://eref.uni-bayreuth.de/id/eprint/14573