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Characterization of the products of the heme detoxification pathway in malarial late trophozoites by X-ray diffraction

Title data

Bohle, D. Scott ; Dinnebier, Robert E. ; Madsen, Sara K. ; Stephens, Peter W.:
Characterization of the products of the heme detoxification pathway in malarial late trophozoites by X-ray diffraction.
In: The Journal of Biological Chemistry. Vol. 272 (1997) . - pp. 713-716.
ISSN 1083-351X
DOI: https://doi.org/10.1074/jbc.272.2.713

Abstract in another language

In a process inhibited by the quinoline antimalarial drugs, Plasmodia detoxify heme released during the degradation of hemoglobin by aggregating it into malarial pigment, an insoluble crystalline heme coordination polymer. Synchrotron x-ray powder diffraction patterns for intact desiccated malarial trophozoites and synthetic beta-hematin have been measured; both materials correspond to a single crystalline triclinic lattice with unit cell parameters a = 12.2176(4), b = 14.7184(5), c = 8.0456(3) A; alpha = 90.200(2), beta = 96.806(3), gamma = 97.818(3) degrees and Z = 2. These results unambiguously demonstrate that hemozoin crystallites are identical to synthetic beta-hematin.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Mathematics, Physics und Computer Science > Group Material Sciences > Chair Crystallography
Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Group Material Sciences
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 530 Physics
Date Deposited: 15 Jun 2016 09:02
Last Modified: 15 Jun 2016 09:02
URI: https://eref.uni-bayreuth.de/id/eprint/32684