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Fully Biodegradable Self-Rolled Polymer Tubes : a Candidate for Tissue Engineering Scaffolds

Title data

Zakharchenko, Svetlana ; Sperling, Evgeni ; Ionov, Leonid:
Fully Biodegradable Self-Rolled Polymer Tubes : a Candidate for Tissue Engineering Scaffolds.
In: Biomacromolecules. Vol. 12 (2011) Issue 6 . - pp. 2211-2215.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm2002945

Abstract in another language

We report an approach for the fabrication of fully biodegradable self-rolled tubes based on patterned polysuccinimide/polycaprolactone bilayers. These polymers are biocompatible, biodegradable, produced industrially, and are already approved for biomedical purposes. Both polycaprolactone and polysuccinimide are hydrophobic and intrinsically water-insoluble. Polysuccinimide, however, hydrolyzes in physiological buffer environment yielding water-swellable polyaspartic acid that causes the rolling of the polymer bilayer and formation of tubes. We demonstrate the possibility to encapsulate yeast cells using self-rolled tubes.We report an approach for the fabrication of fully biodegradable self-rolled tubes based on patterned polysuccinimide/polycaprolactone bilayers. These polymers are biocompatible, biodegradable, produced industrially, and are already approved for biomedical purposes. Both polycaprolactone and polysuccinimide are hydrophobic and intrinsically water-insoluble. Polysuccinimide, however, hydrolyzes in physiological buffer environment yielding water-swellable polyaspartic acid that causes the rolling of the polymer bilayer and formation of tubes. We demonstrate the possibility to encapsulate yeast cells using self-rolled tubes.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Professor Biofabrication
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 21 Jun 2017 11:21
Last Modified: 09 Mar 2022 14:26
URI: https://eref.uni-bayreuth.de/id/eprint/37710