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Reversible Switching of Microtubule Motility Using Thermoresponsive Polymer Surfaces

Title data

Ionov, Leonid ; Stamm, Manfred ; Diez, Stefan:
Reversible Switching of Microtubule Motility Using Thermoresponsive Polymer Surfaces.
In: Nano Letters. Vol. 6 (2006) Issue 9 . - pp. 1982-1987.
ISSN 1530-6992
DOI: https://doi.org/10.1021/nl0611539

Abstract in another language

We report a novel approach for the dynamic control of gliding microtubule motility by external stimuli. Our approach is based on the fabrication of a composite surface where functional kinesin motor-molecules are adsorbed onto a silicon substrate between surface-grafted polymer chains of thermoresponsive poly(N-isopropylacrylamide). By external temperature control between 27 and 35 °C, we demonstrate the reversible landing, gliding, and releasing of motor-driven microtubules in response to conformational changes of the polymer chains. Our method represents a versatile means to control the activity of biomolecular motors, and other surface-coupled enzyme systems, in bionanotechnological applications.We report a novel approach for the dynamic control of gliding microtubule motility by external stimuli. Our approach is based on the fabrication of a composite surface where functional kinesin motor-molecules are adsorbed onto a silicon substrate between surface-grafted polymer chains of thermoresponsive poly(N-isopropylacrylamide). By external temperature control between 27 and 35 °C, we demonstrate the reversible landing, gliding, and releasing of motor-driven microtubules in response to conformational changes of the polymer chains. Our method represents a versatile means to control the activity of biomolecular motors, and other surface-coupled enzyme systems, in bionanotechnological applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Professor Biofabrication
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 22 Jun 2017 15:09
Last Modified: 09 Mar 2022 14:10
URI: https://eref.uni-bayreuth.de/id/eprint/37761