at Google ScholarTitle data
Schmidt, Stephan ; Fernandes, Paulo A. L. ; de Geest, Bruno G. ; Delcea, Mihaela ; Skirtach, Andre G. ; Möhwald, Helmuth ; Fery, Andreas:
Release Properties of Pressurized Microgel Templated Capsules.
In: Advanced Functional Materials.
Vol. 21
(2011)
Issue 8
.
- pp. 1411-1418.
ISSN 1616-3028
DOI: https://doi.org/10.1002/adfm.201002200
Abstract in another language
Direction-specific release induced through osmotic pressure inside giant microcapsules is realized and monitored at high and low concentrations of encapsulated polymer. A clear correlation between the release kinetics upon opening the shell and encapsulated polymer concentration is observed. This has been independently confirmed by shell opening via nanoindentation and laser radiation. To quantify these observations, the internal pressure of the capsules is determined by analysis of mechanical tests performed via colloidal probe AFM. As expected, larger amounts of encapsulated material lead to increased internal pressures and enhanced release kinetics. The results show how drug release can be accelerated by encapsulation of osmotic pressure generating species. Such pressurized capsules systems show large ejection velocities and are envisioned as an inexpensive biolistic transfection device for in vitro applications.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry II - Univ.-Prof. Dr. Andreas Fery Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 500 Natural sciences 500 Science > 530 Physics 500 Science > 540 Chemistry |
| Date Deposited: | 08 Dec 2014 07:17 |
| Last Modified: | 01 Feb 2022 14:18 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/3975 |