at Google ScholarTitle data
Tscheliessnig, Rupert ; Zörnig, Martin ; Herzig, Eva M. ; Lückerath, Katharina ; Altrichter, Jens ; Kemter, Kristina ; Paunel-Görgülü, Adana ; Lögters, Tim ; Windolf, Joachim ; Pabisch, Silvia ; Cinatl, Jindrich ; Rabenau, Holger F. ; Jungbauer, Alois ; Müller-Buschbaum, Peter ; Scholz, Martin ; Koch, Joachim:
Nano-coating protects biofunctional materials.
In: Materials Today.
Vol. 15
(2012)
Issue 9
.
- pp. 394-404.
ISSN 1873-4103
DOI: https://doi.org/10.1016/S1369-7021(12)70166-9
Abstract in another language
The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Juniorprofessor Experimental Physics VII - Dynamics and Structure Formation > Juniorprofessor Experimental Physics VII - Dynamics and Structure Formation - Juniorprof. Dr. Eva M. Herzig Faculties Faculties > Faculty of Mathematics, Physics und Computer Science Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Juniorprofessor Experimental Physics VII - Dynamics and Structure Formation |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 530 Physics |
| Date Deposited: | 06 Oct 2017 09:22 |
| Last Modified: | 20 Oct 2022 11:01 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/39916 |