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General synthesis of primary amines via reductive amination employing a reusable nickel catalyst

Title data

Hahn, Gabriela ; Kunnas, Peter ; de Jonge, Niels ; Kempe, Rhett:
General synthesis of primary amines via reductive amination employing a reusable nickel catalyst.
In: Nature Catalysis. Vol. 2 (2019) . - pp. 71-77.
ISSN 2520-1158
DOI: https://doi.org/10.1038/s41929-018-0202-6

Abstract in another language

Reusable catalysts based on earth-abundant metals with a broad applicability in organic synthesis are a key to a more sustainable production of fine chemicals, pharmaceuticals and agrochemicals. Herein, we report on a nanostructured nickel catalyst for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. Our catalyst, which operates at low temperature and pressure, is highly active, reusable and easy to handle. The synthesis from a specific nickel complex and γ-Al2O3 is straightforward, with the ligand–metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl–alkyl, dialkyl and diaryl ketones can all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products is demonstrated. Many functional groups—including hydrogenation-sensitive examples—are tolerated. We expect that our findings will inspire others to develop reusable and nanostructured earth-abundant metal catalysts for complex organic transformations.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 Dec 2018 08:02
Last Modified: 17 Jan 2019 09:12
URI: https://eref.uni-bayreuth.de/id/eprint/46745