Literature by the same author
plus at Google Scholar

Bibliografische Daten exportieren
 

1H-NMR studies of the natriuretic peptide urodilatin : Sequence-specific resonance assignments

Title data

Weber, Joachim ; Rösch, Paul ; Adermann, Knut ; Forssmann, Wolf-Georg ; Wokaun, Alexander:
1H-NMR studies of the natriuretic peptide urodilatin : Sequence-specific resonance assignments.
In: Biochimica et Biophysica Acta : Protein Structure and Molecular Enzymology. Vol. 1207 (1994) Issue 2 . - pp. 231-235.
ISSN 0167-4838
DOI: https://doi.org/10.1016/0167-4838(94)00040-9

Abstract in another language

The recently discovered 32 amino-acid natriuretic peptide urodilatin was chemically synthesized and subjected to two-dimensional proton nuclear magnetic resonance (NMR) spectroscopy studies in aqueous solution in order to determine the structural state of urodilatin. In contrast to earlier studies on very closely related peptides, such as cardiodilatin (CDD/ANP-99-126) and brain natriuretic peptide (BNP), spectra of urodilatin were extremely well resolved even in millimolar concentration in H2O so that the complete sequence specific resonance assignments could be achieved. No long range NOEs could be detected, except between residues close to the single cystine bond. This leads to the conclusion that urodilatin in aqueous solution is a random coil peptide with the exception of the region around the cystine bond.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry with an Emphasis on Biophysical Chemistry
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 10 Jan 2019 10:27
Last Modified: 31 Mar 2022 13:19
URI: https://eref.uni-bayreuth.de/id/eprint/46843