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General and selective deoxygenation by hydrogen using a reusable earth-abundant metal catalyst

Title data

Schwob, Tobias ; Kunnas, Peter ; de Jonge, Niels ; Papp, Christian ; Steinrück, Hans-Peter ; Kempe, Rhett:
General and selective deoxygenation by hydrogen using a reusable earth-abundant metal catalyst.
In: Science Advances. Vol. 5 (2019) Issue 11 . - No. eaav3680.
ISSN 2375-2548
DOI: https://doi.org/10.1126/sciadv.aav3680

Abstract in another language

Chemoselective deoxygenation by hydrogen is particularly challenging but crucial for an efficient late-stage modification of functionality-laden fine chemicals, natural products, or pharmaceuticals and the economic upgrading of biomass-derived molecules into fuels and chemicals. We report here on a reusable earth-abundant metal catalyst that permits highly chemoselective deoxygenation using inexpensive hydrogen gas. Primary, secondary, and tertiary alcohols as well as alkyl and aryl ketones and aldehydes can be selectively deoxygenated, even when part of complex natural products, pharmaceuticals, or biomass-derived platform molecules. The catalyst tolerates many functional groups including hydrogenation-sensitive examples. It is efficient, easy to handle, and conveniently synthesized from a specific bimetallic coordination compound and commercially available charcoal. Selective, sustainable, and cost-efficient deoxygenation under industrially viable conditions seems feasible.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 21 Nov 2019 07:59
Last Modified: 31 Jan 2022 10:14
URI: https://eref.uni-bayreuth.de/id/eprint/53337