at Google ScholarTitle data
Schlagbauer, Martin ; Kallmeier, Fabian ; Irrgang, Torsten ; Kempe, Rhett:
Manganese catalyzed ß‐methylation of alcohols by methanol.
In: Angewandte Chemie International Edition.
Vol. 59
(2020)
Issue 4
.
- pp. 1485-1490.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201912055
Abstract in another language
We report an earth‐abundant metal catalyzed double and single methylation of alcohols. A manganese catalyst, which operates at low catalyst loadings and short reaction times, mediates these reactions efficiently. A broad scope of primary and secondary alcohols including purely aliphatic examples and 1,2‐aminoalcohols can be methylated. In addition, alcohol methylation for the synthesis of pharmaceuticals has been demonstrated. The catalyst system tolerates many functional groups among them hydrogenation sensitive examples and upscaling is easily achieved. Mechanistic investigations are indicative of a borrowing hydrogen or hydrogen autotransfer mechanism involving a bimetallic K‐Mn catalyst. The catalyst accepts hydrogen as a proton and a hydride from alcohols efficiently and reacts with a chalcone via hydride transfer.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Additional notes: | early view |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 21 Nov 2019 08:04 |
| Last Modified: | 27 Jan 2022 14:14 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/53355 |