bei Google ScholarTitelangaben
Jäger, Hubert ; Rauch, Melanie ; Heidmann, Stefan:
The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H₃ variant CID.
In: Chromosoma.
Bd. 113
(2005)
Heft 7
.
- S. 350-361.
ISSN 1432-0886
DOI: https://doi.org/10.1007/s00412-004-0322-4
Abstract
The centromere-specific histone H3 variant CENP-A plays a crucial role in kinetochore specification and assembly. We chose a genetic approach to identify interactors of the Drosophila CENP-A homolog CID. Overexpression of cid in the proliferating eye imaginal disk results in a rough eye phenotype, which is dependent on the ability of the overexpressed protein to localize to the kinetochore. A screen for modifiers of the rough eye phenotype identified mutations in the Drosophila condensin subunit gene Cap-G as interactors. Yeast two-hybrid experiments also reveal an interaction between CID and Cap-G. While chromosome condensation in Cap-G mutant embryos appears largely unaffected, massive defects in sister chromatid segregation occur during mitosis. Taken together, our results suggest a link between the chromatin condensation machinery and kinetochore structure.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | mitotic chromosome architecture; sister chromatid segregation; cell-cycle progression; vertebrate cells; topoisomerase-II; caenorhabditis-elegans; CENP-C; protein; mitosis; segregation |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Genetik Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
| Eingestellt am: | 06 Mär 2020 10:52 |
| Letzte Änderung: | 06 Mär 2020 11:02 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/54533 |