at Google ScholarTitle data
Jäger, Hubert ; Rauch, Melanie ; Heidmann, Stefan:
The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H₃ variant CID.
In: Chromosoma.
Vol. 113
(2005)
Issue 7
.
- pp. 350-361.
ISSN 1432-0886
DOI: https://doi.org/10.1007/s00412-004-0322-4
Abstract in another language
The centromere-specific histone H3 variant CENP-A plays a crucial role in kinetochore specification and assembly. We chose a genetic approach to identify interactors of the Drosophila CENP-A homolog CID. Overexpression of cid in the proliferating eye imaginal disk results in a rough eye phenotype, which is dependent on the ability of the overexpressed protein to localize to the kinetochore. A screen for modifiers of the rough eye phenotype identified mutations in the Drosophila condensin subunit gene Cap-G as interactors. Yeast two-hybrid experiments also reveal an interaction between CID and Cap-G. While chromosome condensation in Cap-G mutant embryos appears largely unaffected, massive defects in sister chromatid segregation occur during mitosis. Taken together, our results suggest a link between the chromatin condensation machinery and kinetochore structure.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | mitotic chromosome architecture; sister chromatid segregation; cell-cycle progression; vertebrate cells; topoisomerase-II; caenorhabditis-elegans; CENP-C; protein; mitosis; segregation |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 570 Life sciences, biology |
| Date Deposited: | 06 Mar 2020 10:52 |
| Last Modified: | 06 Mar 2020 11:02 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/54533 |