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RNA editing in kinetoplastid protozoa

Titelangaben

Stuart, Kenneth ; Allen, Thomas E. ; Heidmann, Stefan ; Seiwert, Scott D.:
RNA editing in kinetoplastid protozoa.
In: Microbiology and Molecular Biology Reviews. Bd. 61 (1997) Heft 1 . - S. 105-120.
ISSN 1098-5557

Volltext

Link zum Volltext (externe URL): Volltext

Abstract

Mitochondrial transcripts in kinetoplastids undergo remarkable posttranscriptional editing by uridylate insertion and deletion. The often dramatic remodelling of pre-mRNA sequences is directed by small guide RNAs (gRNAs) to produce mature mRNAs. In vitro analyses of editing have been used to determine the mechanism of editing and show that editing occurs by a series of enzyme-catalyzed steps. They also show that chimeric gRNA/mRNA molecules are not editing intermediates as proposed but are aberrant end products of editing. The complexes and molecules that catalyze editing are now being identified and characterized. The origin of editing, its developmental regulation which helps control the switching between terminal respiratory systems during the life cycle of trypanosomes, and other areas for future study are discussed.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: Mitochondrial Ribonucleoprotein Complexes; Leishmania-Tarentolae Mitochondria; Trypanosoma-Brucei Mitochondria; Multiple Guide RNAS; Life-Cycle Stages; B Messenger-RNA; Crithidia-Fasciculata; NADH Dehydrogenase; Maxicircle DNA; Reading Frames
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Genetik
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
Eingestellt am: 12 Mär 2020 12:48
Letzte Änderung: 28 Apr 2022 11:28
URI: https://eref.uni-bayreuth.de/id/eprint/54608