Title data
Hassan, Amira ; Rodriguez, Pablo Araguas ; Heidmann, Stefan ; Walmsley, Emma L. ; Aughey, Gabriel N. ; Southall, Tony D.:
Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons.
In: eLife.
Vol. 9
(2020)
.
- e55159.
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.55159
Abstract in another language
Condensin complexes are essential for mitotic chromosome assembly and segregation during cell divisions, however, little is known about their functions in post-mitotic cells. Here we report a role for the condensin I subunit Cap-G in Drosophila neurons. We show that, despite not requiring condensin for mitotic chromosome compaction, post-mitotic neurons express Cap-G. Knockdown of Cap-G specifically in neurons (from their birth onwards) results in developmental arrest, behavioural defects, and dramatic gene expression changes, including reduced expression of a subset of neuronal genes and aberrant expression of genes that are not normally expressed in the developing brain. Knockdown of Cap-G in mature neurons results in similar phenotypes but to a lesser degree. Furthermore, we see dynamic binding of Cap-G at distinct loci in progenitor cells and differentiated neurons. Therefore, Cap-G is essential for proper gene expression in neurons and plays an important role during the early stages of neuronal development.
Further data
Item Type: | Article in a journal |
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Refereed: | Yes |
Institutions of the University: | Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology |
Result of work at the UBT: | No |
DDC Subjects: | 500 Science 500 Science > 570 Life sciences, biology |
Date Deposited: | 22 Apr 2020 06:10 |
Last Modified: | 11 Apr 2024 10:09 |
URI: | https://eref.uni-bayreuth.de/id/eprint/54988 |