Literature by the same author
plus at Google Scholar

Bibliografische Daten exportieren
 

Interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa

Title data

Fuchs, Florian ; Prokisch, Holger ; Neupert, Walter ; Westermann, Benedikt:
Interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa.
In: Journal of Cell Science. Vol. 115 (2002) Issue 9 . - pp. 1931-1937.
ISSN 1477-9137

Abstract in another language

The establishment and maintenance of the 3D structure of eukaryotic cells depends on active transport and positioning of organelles along cytoskeletal elements. The biochemical basis of these processes is only poorly understood. We analysed the interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa. Mitochondria were fluorescently labelled by expression of matrix-targeted green fluorescent protein. Upon isolation, mitochondria collapsed to round spherical structures that were still able to interact with microtubules in vitro. Binding of mitochondria to microtubules was dependent on peripherally associated proteins on the organellar surface, and was sensitive to adenine nucleotides. MMM1, a mitochondrial outer membrane protein important for maintenance of normal mitochondrial morphology, was not required. This suggests that the interaction of mitochondria with the cytoskeleton is independent of MMM1. We conclude that mitochondrial morphology is maintained by a complex interplay of extrinsic and intrinsic factors, including ATP-dependent proteins on the organellar surface.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Professor Cell Biology > Professor Cell Biology - Univ.-Prof. Dr. Benedikt Westermann
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Professor Cell Biology
Result of work at the UBT: No
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 20 Oct 2020 11:20
Last Modified: 20 Oct 2020 11:20
URI: https://eref.uni-bayreuth.de/id/eprint/58206