at Google ScholarTitle data
Breuning, Matthias ; Winnacker, Malte ; Steiner, Melanie:
Efficient One-Pot Synthesis of Enantiomerically Pure 2-(Hydroxymethyl)morpholines.
In: European Journal of Organic Chemistry.
(2007)
Issue 13
.
- pp. 2100-2106.
ISSN 1099-0690
DOI: https://doi.org/10.1002/ejoc.200601006
Abstract in another language
An efficient and convenient one-pot procedure for the synthesis of enantiomerically pure 2-(hydroxymethyl)morpholines with a widely variable substitution pattern was developed. Addition of chiral β-amino alcohols to (S)- or (R)-epichlorohydrin in the presence of LiClO4 afforded the corresponding chloro alcohols, which were treated with NaOMe to give the epoxides and, by subsequent intramolecular cyclization, the target compounds in good yields (57–77 %).
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professor Organic Chemistry > Professor Organic Chemistry - Univ.-Prof. Dr. Matthias Breuning Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professor Organic Chemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 11 Jan 2022 14:47 |
| Last Modified: | 11 Jan 2022 14:47 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/68320 |