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Bringmann, Gerhard ; Tasler, Stefan ; Pfeifer, Robert-M. ; Breuning, Matthias:
The directed synthesis of axially chiral ligands, reagents, catalysts, and natural products through the "lactone methodology".
In: Journal of Organometallic Chemistry.
Bd. 661
(2002)
Heft 1-2
.
- S. 49-65.
ISSN 0022-328X
DOI: https://doi.org/10.1016/S0022-328X(02)01819-3
Abstract
Axially chiral biaryls have become increasingly important during the past years—as structurally, biosynthetically, and pharmacologically remarkable natural products, but also as useful tools in asymmetric synthesis: as chiral reagents, ligands, and catalysts. Nevertheless, only few generally applicable synthetic protocols for the atropo-enantio- or -diastereoselective construction of biaryl bonds have been developed. The ‘lactone methodology’ as described in detail in the preceeding article, provides directed, atropo-divergent access to any of the two respective atropisomers starting from the identical immediate precursor, a (usually) configurationally unstable, since lactone-bridged biaryl. In this article the efficiency of the ‘lactone method’ in the total synthesis of natural products and in the preparation of axially chiral ligands is demonstrated for selected examples.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | Biaryl axis; Asymmetric synthesis; Natural products; Biaryl ligands; Axial chirality; Enantioselective catalysis |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Organische Chemie > Professur Organische Chemie - Univ.-Prof. Dr. Matthias Breuning Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Organische Chemie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 12 Jan 2022 09:59 |
| Letzte Änderung: | 12 Jan 2022 09:59 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/68335 |