at Google ScholarTitle data
Clemens, Stephan:
The cell biology of Zn.
In: Journal of Experimental Botany.
Vol. 73
(2022)
Issue 6
.
- pp. 1688-1698.
ISSN 1460-2431
DOI: https://doi.org/10.1093/jxb/erab481
Abstract in another language
Nearly 10% of all plant proteins belong to the zinc (Zn) proteome. They require Zn either for catalysis or as a structural element. Most of the protein-bound Zn in eukaryotic cells is found in the cytosol. The fundamental differences between transition metal cations in the stability of their complexes with organic ligands, as described by the Irving–Williams series, necessitate buffering of cytosolic Zn (the ‘free Zn’ pool) in the picomolar range (i.e. ~6 orders of magnitude lower than the total cellular concentration). Various metabolites and peptides, including nicotianamine, glutathione, and phytochelatins, serve as Zn buffers. They are hypothesized to supply Zn to enzymes, transporters, or the recently identified sensor proteins. Zn2+ acquisition is mediated by ZRT/IRT-like proteins. Metal tolerance proteins transport Zn2+ into vacuoles and the endoplasmic reticulum, the major Zn storage sites. Heavy metal ATPase-dependent efflux of Zn2+ is another mechanism to control cytosolic Zn. Spatially controlled Zn2+ influx or release from intracellular stores would result in dynamic modulation of cellular Zn pools, which may directly influence protein–protein interactions or the activities of enzymes involved in signaling cascades. Possible regulatory roles of such changes, as recently elucidated in mammalian cells, are discussed.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | Endoplasmic reticulum; Metal homeostasis; Micronutrient; Signaling; Transport; Zn homeostasis |
| Institutions of the University: | Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Plant Physiology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Plant Physiology > Chair Plant Physiology - Univ.-Prof. Dr. Stephan Clemens Faculties > Faculty of Life Sciences: Food, Nutrition and Health |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science 500 Science > 500 Natural sciences 500 Science > 570 Life sciences, biology |
| Date Deposited: | 17 Jan 2022 08:57 |
| Last Modified: | 04 Jul 2022 13:18 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/68364 |