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4D Biofabrication of Mechanically Stable Tubular Constructs Using Shape Morphing Porous Bilayers for Vascularization Application

Title data

Trujillo-Miranda, Mairon ; Apsite, Indra ; Rodríguez Agudo, Jose A. ; Constante Ibarra, Gissela Katherine ; Ionov, Leonid:
4D Biofabrication of Mechanically Stable Tubular Constructs Using Shape Morphing Porous Bilayers for Vascularization Application.
In: Macromolecular Bioscience. Vol. 23 (2023) Issue 1 . - 2200320.
ISSN 1616-5195

Official URL: Volltext

Project information

Project financing: DFG Grant No. IO 68/17-1, IO 68/14-1

Abstract in another language

This study reports fabrication of highly porous electrospun self-folding bilayers, which fold into tubular structures with excellent mechanical stability, allowing them to be easily manipulated and handled. We fabricated and compared two kinds of bilayers based on FDI-approved biocompatible and biodegradable soft (PCL, polycaprolactone) and hard (PHB, poly-hydroxybutyrate) thermoplastic polymers. Multi-scroll structures with tunable diameter in aqueous media were obtained after the shape transformation of the bilayer, where PCL-based bilayer rolled longitudinally and PHB-based one rolled transversely with respect to fiber direction. A combination of higher elastic modulus and transverse orientation of fibers with respect to rolling direction allowed precise temporal control of shape transformation of PHB-bilayer – stress produced by swollen methacrylated hyaluronic acid (HA-MA) did not relax with time and folding was not affected by the fact that bilayer was fixed in unfolded state in cell culture medium for more than 1 h. This property of PHB-bilayer allowed cell culturing without negative effect on its shape transformation ability. Moreover, PHB-based tubular structure demonstrated superior mechanical stability compared to PCL-based ones and did not collapse during manipulations that happened to PCL-based one. Additionally, PHB/HA-MA bilayers showed superior biocompatibility, degradability, and long-term stability compared to PCL/HA-MA. After 14 days of cultivation, our vascular grafts showed high stability in cultivation, and between 50–70% of the multi-scroll area was fully covered. All these make bilayer of transversely aligned hard thermoplastic polymer fibers (such as PHB) and swelling hydrophilic polymer fibers (such as HA-MA) more suitable for the fabrication of blood vessel replacement in comparison to widely used PCL-based bilayers.

Further data

Item Type: Article in a journal
Refereed: No
Keywords: fibrous scaffolds; self-folding; vascular graft; electrospun bilayer
Institutions of the University: Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Professor Biofabrication
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 06 Oct 2022 11:18
Last Modified: 01 Aug 2023 13:22