at Google ScholarTitle data
Bräutigam, Katharina ; Bocklitz, Thomas ; Schmitt, Michael ; Rösch, Petra ; Popp, Jürgen:
Raman spectroscopic imaging for the real-time detection of chemical changes associated with docetaxel exposure.
In: ChemPhysChem.
Vol. 14
(2013)
Issue 3
.
- pp. 550-553.
ISSN 1439-4235
DOI: https://doi.org/10.1002/cphc.201200800
Abstract in another language
There is an urgent need for methods allowing for a fast, non-invasive, sensitive and selective monitoring of the effectiveness of anticancer drugs during the course of a chemotherapeutic treatment of cancer patients. The possibility of predicting and controlling the efficiency of chemotherapeutic agents for every patient individually enables a personalized therapy with largely improved success rates. The results presented herein demonstrate that Raman microspectroscopy is perfectly suited to monitor the impact of chemotherapeutic agents on living cells. The influence of the clinically well-established chemotherapeutic docetaxel on both the morphology and also biochemistry of living colon cancer cells (HT-29) has been studied by means of Raman spectroscopy in combination with modern chemometric approaches. The work presented paves the way for establishing Raman spectroscopy as a monitoring tool of the effectiveness of a chemotherapy treatment and can therefore be seen as a step towards personalized therapy.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Computer Science > Lehrstuhl Künstliche Intelligenz in der Mikroskopie und Spektroskopie > Lehrstuhl Künstliche Intelligenz in der Mikroskopie und Spektroskopie - Univ.-Prof. Dr. Thomas Wilhelm Bocklitz |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 530 Physics |
| Date Deposited: | 19 May 2023 10:14 |
| Last Modified: | 19 May 2023 10:14 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/76293 |